Progesterone Side Effects & What to Expect

Micronized progesterone is generally well-tolerated. Most side effects are mild and tend to improve over time.

More Common Side Effects

• Drowsiness or dizziness (most common; taking at bedtime helps manage this)
• Breast tenderness
• Headache
• Mood changes
• Bloating or fluid retention
• Spotting or breakthrough bleeding, or changes in period patterns

Less Common Side Effects

• Nausea
• Fatigue
• Acne or oily skin

Signs of an Allergic Reaction

Stop using progesterone and seek emergency care immediately if you experience:

• Difficulty breathing
• Swelling of your face, lips, tongue, or throat

Other Important Safety Information

• Do not use progesterone if you are pregnant or breastfeeding.
• Progesterone may affect mood; if you have a history of depression or anxiety, your provider will monitor you closely.
• Contact your provider if you experience unexpected vaginal bleeding.
• Do not share your prescription with others.

When to Contact Your Provider

Reach out through the Patient Portal or at [e-mail] if you experience:

• Side effects that persist or worsen
• Unexpected vaginal bleeding
• Mood changes that concern you

Manage your subscription, view your orders, or message your care team anytime through your Patient Portal.